PharmGKBEvidenceLevelCustomCS

PharmGKB Evidence Level Example Codes

activeGenomics Reporting3.0.0complete6 concepts

PharmGKB contains examples of evidence level concepts that are not conflated with clinical significance. These can be found on PharmGKB https://www.pharmgkb.org/page/clinAnnLevels. These examples are informational only, for copyright information contact the relevant source.

Metadata

hl7.org/fhir
Canonical URL
http://hl7.org/fhir/uv/genomics-reporting/CodeSystem/pharmgkb-evidence-level-custom-cs
ID
pharmgkb-evidence-level-custom-cs
Version
3.0.0
Publisher
HL7 International / Clinical Genomics
Case Sensitive
Yes

Concepts (6)

CodeDisplayDefinition
1APGKB 1AHigh level of evidence. Supported by a guideline or FDA label with variant specific prescribing guidance. Additionally, supported by at least one publication.
1BPGKB 1BHigh level of evidence. But, NOT supported by a guideline or FDA label with variant specific prescribing guidance. Additionally, supported by at least one publication.
2APGKB 2AModerate level of evidence. Supported by being a KNOWN pharmacogene on https://www.pharmgkb.org/vips. Also, found in multiple studies but may have a minority of studies that did not support the majority opinion. Supported by at least two indpendent publications.
2BPGKB 2BModerate level of evidence. NOT in the list of very important, KNOWN pharmacogenes. Found in multiple studies but may have a minority of studies that did not support the majority opinion. Supported by at least two indpendent publications.
3PGKB 3Low-level of evidence. Where either the assocation is based on a single study, failed to be reproduced, or preliminary evidence.
4PGKB 4The evidence does not support an association between the variant and the drug phenotype. (negative)